| abstract |
Novel pyrimido(1',6':1,2) pyrido (3,4-B)indole derivs. of general formula (I). (Where Q = 1-4C alkoxy, hydrazino gp. or NR1R2; where R1 = 1-4C alkyl gp. R2 = H atom or R1 and R2 together from a 4-6C straight chain alkylene gp) are prepd. from 1-benzyl-3,4 -di-hydro-pyrido(3,4-B) indole cpd. of general formula (II) (where X(-):a halide ion-, or its base and practically in molar equiv. quantity of a glycine-ester-hydrogen halide salt of general formula X(-)H3(+)NCH2COOR1 in the presence of mol. equiv. organic base and from at least to mol-equivs. of formaldehyde. The reaction mix is treated with sodium-borohydride and opt. when Q is a 1-4C alkoxy gp. in (1), then they are reacted with hydrazine or an amine of general formula NHR1R2 (IV). |