| abstract |
The invention provides N-imidazolyl derivatives of substituted indole of general formula (I)n nwhereinn p is an integer of 1 to 4; A is a straight or branched C 1 -C 4 alkylene chain; B is a direct linkage, a straight or branched, unsaturated or saturated C 1 -C 4 hydrocarbon chain; Q is a straight or branched, saturated or unsaturated C 1 -C 9 hydrocarbon chain, or said chain is interrupted by an oxygen atom; each of R 1 and R 2 independently is hydrogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, C 1 -C 4 alkylsulfonyl, halogen or trihalomethyl; each of R 3 and R s , independently, is hydrogen or C 1 -C 4 alkyl; R 4 is a -OR 6 or -N(R 6 R 7 ) group, wherein each of R 6 and R 7 independently is hydrogen, C 1 -C 4 alkyl, phenyl or benzyl; or a pharmaceutically acceptable salt thereof, which are useful in the treatment of a disease state in which an enhancement of TxA 2 synthesis exerts a pathogenic effect. |