| abstract |
7-Oxabicycloheptane imidazole prostaglandin analogs are provided which are useful in treating thrombotic and vasospastic disease and have the structural formula <CHEM> wherein m is 1, 2 or 3; n is 1, 2 or 3 and p is 1, 2 or 3; R is CO2H, CO2lower alkyl, CO2alkali metal, CONHSO2R2 (wherein R2 is lower alkyl or aryl) or 5-tetrazolyl; A is CHOH, C=O, <CHEM> (wherein R3 is H or lower alkyl), or a single bond; R1 is lower alkyl, aryl, cycloalkyl or H, R1 can be H only when A is a single bond. |