| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0249c8c96ed09a989cb0d43c51a3060d |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-00 |
| filingDate |
2009-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e65d5de44930bc69a4b1176c5add126
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a754dea2216fdad72a655880ae19a998
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_170c03755abb8ef0c5ac9afd4c80d6a2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee9682e1ce9f52bca72ec8a63dba7635
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_310ee18a1ef0abf136c0b2c6563dda90 |
| publicationDate |
2016-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
HU-E026181-T2 |
| titleOfInvention |
Ketoreductase polypeptide for the preparation of 3-aryl-3-hydroxypropanamine from 3-aryl-3-ketopropanamine |
| abstract |
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N,N-dimethyl-3-keto-3-(2-thienyl)-1-ketopropanamine to (S)-N,N-dimethyl-3-hydroxy-3-(2-thienyl)-1-propanamine. |
| priorityDate |
2008-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |