abstract |
A compound that has the structure of Formula (XII):n nwherein, nX 1 is CH, CR 3 or N; nX 2 is N, CH, or CR 3 ; nZ is -OH or -OR 10 ; nR 2 is C 1 -C 4 alkyl, C 1 -C 4 fluoroalkyl, C 1 -C 4 deuteroalkyl, C 3 -C 6 cycloalkyl, or -C 1 -C 4 alkylene-W; nW is hydroxy, halogen, CN, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy, and C 3 -C 6 cycloalkyl; neach R 3 is independently halogen, C 1 -C 4 alkyl, or C 1 -C 4 fluoroalkyl; neach R 4 is independently halogen, -CN, -OR 9 , -S(=O) 2 R 10 , C 1 -C 4 alkyl, C 1 -C 4 fluoroalkyl, or C 1 -C 4 heteroalkyl; neach R 5 is independently halogen, -CN, -OR 9 , -S(=O) 2 R 10 , C 1 -C 4 alkyl, C 1 -C 4 fluoroalkyl, or C 1 -C 4 heteroalkyl; nR 6 is H, C 1 -C 4 alkyl, or halogen; nR 7 is H, C 1 -C 4 alkyl, or halogen; nR 9 is H, C 1 -C 6 alkyl, C 1 -C 6 fluoroalkyl, or C 3 -C 6 cycloalkyl; nR 10 is C 1 -C 6 alkyl; nm is 0, 1, or 2; nn is 0, 1, 2, 3, or 4; and np is 0, 1, or 2; nor a pharmaceutically acceptable or N-oxide thereof. |