| abstract |
FIELD OF THE INVENTION The present invention relates to IP receptor modulator compounds of formula (I) wherein R1 and R2 are independently alkyl, aryl, aralkyl, heteroaryl, cycloalkyl or heterocyclic; R3 and R4 are independently hydrogen, alkyl, alkoxy. , amino, halogen, haloalkyl, hydroxyalkyl, nitro, aryl, aralkyl or heterocyclic; R5 is -COOR6 or tetrazolyl; R6 is hydrogen or alkyl; A is alkylene or alkenylene; -O (CH2) m- or - (CH2) n-; m is 1-8; and n is 0-8), their individual isomers, racemic or non-racemic mixtures of isomers, and their pharmaceutically acceptable salts and solvates. The invention further relates to pharmaceutical compositions comprising the above compounds and to their use as pharmaceutical active ingredients. HE |