| abstract |
The present invention relates to the preparation of compounds of formula I wherein A is C 1-6 alkyl; or aryl mono- or di-substituted with fluorine, chlorine or bromine, -OCH3, alkyl having 1-3 carbon atoms or benzyl. A preferred compound of formula (I) is that wherein A is methyl. The 5-lipoxygenase inhibitors of the present invention selectively inhibit the function of the alipoxygenase enzyme and thereby are useful in the treatment of inflammatory or cardiovascular diseases or allergies in mammals. Some of the compounds of formula I are new. The invention also relates to novel intermediates of formula (IV), (V), (VI), (VII), (VIII). SHE |