| abstract |
In the general formula (1) of the compounds according to the invention, the substituents R1-R5 and R8 represent optionally substituted alkyl, aryl, aralkyl or heteroatoms containing a heteroatom. The present invention relates to pharmaceutically acceptable salts, stereoisomeric salts and pharmaceutically acceptable salts thereof. (hydrates). The compounds of the present invention are useful for the inhibition of matrix metalloprotease (MMP) in a patient in need thereof who has acute or chronic inflammatory or neoplastic disease, or any condition that is severely pathologic or mediated by MMP. ŕ |