http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-9903836-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-38 |
| filingDate | 1997-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93874dd858a3fc7ba8ac42e902d14ba7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4a3190e54d6e76d73d3033ef485b757 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_049808631efc7ef0e5851528f9885f06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f74fcf1552da97dacaa79477e5fd5bd6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5bc52739bb5ba9f97a0d5a7ea14cd98 |
| publicationDate | 2001-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-9903836-A2 |
| titleOfInvention | New Method for the Preparation of Cox-2 Inhibitory Phenyl-Substituted 2 (5H) -furanones |
| abstract | The present invention relates to a process for the preparation of compounds of formula I wherein R2 is mono- or disubstituted phenyl wherein the substituent is (1) hydrogen, (2) halogen, (3) C 1-6 -alkoxy, (4) C 1-6 -alkyl -thio, (5) cyano, (6) trifluoromethyl, and / or (7) C 1-6 alkyl, R 3 and R 3 'are independently hydrogen or C 1-4 alkyl, wherein (b4) reacting a compound of general formula (2) in N, N-dimethylformamide with a phenylacetic acid of general formula R2-CH2-CO2H in the presence of an inorganic base to form a compound of general formula (5a), (b5) a polar aprotic solvent. with an organic base to form a compound of formula (1). SHE |
| priorityDate | 1996-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.