| abstract |
The present invention relates to a topical gel composition comprising: a) about 0.1% to about 10% by weight of a non-steroidal anti-inflammatory drug, which may be a propionic acid, acetic acid, phenamic acid, biphenylcarboxylic acid derivative and an oxicam or salts thereof; b) from about 0.1% to about 10% by weight of a xanthine derivative of formula II wherein R1, R2 and R3 are independently hydrogen, methyl or ethyl and at least two of R1, R2 and R3 are methyl or ethyl, or mixtures thereof; c) about 0.5 to 10% by weight of a gelling agent; d) from about 5% to about 60% by weight of a co-solvent for the non-steroidal anti-inflammatory and xanthine derivative; and e) about 10% to about 90% water by weight. The compositions of the present invention exhibit excellent stability, excellent transparency, analgesic and anti-inflammatory properties. SHE |