| abstract |
The present invention relates to novel thiophene derivatives of general formula (I) useful as an anti-PCP agonist and to pharmaceutical compositions containing such compounds. In the general formula (I), R1 is -A1-X1-R3 anthers, R2 is -A2-X2-R4 anthers or is absent, Ring B is 1) a 4- to 10-membered cyclic alkyl ring containing 2 or 5 genes; or a 6-membered nitrogen-containing unsaturated heterocyclic bicarbonate, the Ar ring being an optionally substituted aryl ring or a 5 or 6-membered aromatic heterocyclic bicarbonate, or an 8-10 membered aromatic bicyclic bicyclic bicyclic, , comprising a heteroatom selected from nitrogen, oxy and sulfur, A1, A2 and A3 represent a chemical bond or a lower alkylene piper, X1 and X2 represent a chemical bond or a sulfur, or a sulfur, or R5, R6, R7, R8, R9, R10, R11, R12 and R13 are married or different R3 and R4 are hydrogen or lower alkyl, or optionally aryl or aryl, aryl or aryl, aryl or aryl, aryl or aryl; when the Ar ring is a thiazole ring, one of A1 and A2 is a lower alkylene piperidine, and if the Ar ring is a benzene ring, those compounds in which one of R1 and R2 is methyltube or halogen are excluded, and the other is hydrogen. ŕ |