| abstract |
The present invention relates to derivatives of antiangiogenic and / or vascular permeability (I) derivatives of general formula (I) and salts thereof, wherein m is 1 or 2, the hydrogens of R 1, the halogen nucleator, or the hydroxyl, nitro, trifluoro-methyl, cyano, alkyl. , alkyloxy, alkylthio or -NR5R8 tuberite, R2 hydrogens, halogen or hydrogen, methyl, methoxy, amine, or nitrile radicals; methyl, cyano, amine, or nitrile pipe shells, X1 -O-, -CH2-, -S-, -SO-, -NR7CO-, -CONR8-, -SO2NR9-, -NR10SO2- or -NR11- in which R7, R8, R9, R10 and R11 are independently hydrogen, alkyl or alkyloxyalkyl, and R4 is an unsubstituted or disubstituted alkylpiper. (I) |