| abstract |
Compounds of general formula (I) (wherein Ar1 is optionally substituted phenyl, naphthyl or tetrahydronaphthyl substituted by hydroxy, lower alkoxy, nitro, amino or methanesulfonic acid; Ar2 is optionally substituted by lower alkyl or lower alkyl; x, C, CH, C (OH) or N; Y is -CH2-, CH or O; Z is -CH2-, -CH (CH3) - or -C; (CH 3) 2 -; R 1 is hydrogen, lower alkyl or acetyl piperidine; A is C = O or - (CHR 2) n -, of which R 2 is hydrogen, lower alkyl or hydroxy (lower alkyl) piperidine; - (CH 2) n -, -O-, -CH (OH) (CH 2) n -, -CH (CH 2 OH) (CH 2) n, - (CH 2) n CH (OH) - or -CH (CH 2 OH) -; - represents an optional bond and n is 0-4) and their use of pharmaceutically acceptable acid addition salts is specific NMDA receptor has been found to be effective in the preparation of pharmaceutical compositions in the therapeutic indications of subtypical blacks. (I) ŕ |