| abstract |
FIELD OF THE INVENTION The present invention relates to free base or pharmaceutically acceptable acid addition salts of cerebral (4-oxy-3-aryl-phenyl) -azaryl or -aryl-carbonyloxy-derivatives which are useful as medicaments for the treatment and prevention of inflammatory diseases, particularly respiratory asthma. Preferred compounds of the invention are the new phenylphenylpyridines, biphenylbenzamides and phenylbiphenylcarboxylic acids. The compounds of the invention are selective inhibitors of the PDE 4 isozyme activity and reduce or inhibit the release of TNF-α. ŕ |