| abstract |
In the general formula (I) of the compounds of the present invention, A is H, optionally substituted D, La-hydroxyacetyl, R1, R1-OC (O) -, R1-C (O) -, R1-SO2-, R2OOC- ( CHR2) m-SO2-, R2OOC- (CHR2) m-, H2NCO- (CHR2) m, or an N-protecting group in which R1 and R2 are optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl -, aralkyl or aralkenyl pipes, or R2 may also represent a hydrogen power plant; m is 1, 2 or 3, B is a bond or a pipeline of the formula -NH-CH [(CH2) pC (O) OH] -C (O) - or an ester derivative thereof, of which p is 0, 1, 2 or 3, and more -N-alkyl-CH2-CO-, -N-alkenyl-CH2-CO-, -N-alkynyl-CH2-CO-, -N-benzyl-CH2-CO-, D-1-Tiq, D-3- Tiq, D-Atc, Aic, D-1-Piq, D-3-Piq or an L- or D-amino acid pipeline containing a hydrophobic basic or neutral lead chain, A and B together are an R3R4N-CHR5-C ( O) - a tube of the general formula wherein R3 and R4 are independently R1, R1-OC (O) -, R1-C (O) -, R1-SO2-, R2OOC- (CHR2) m-SO2-, R2OOC- (CHR2 ) m-, H2NCO- (CHR2) m- or a N-protective tube, or one of R3 and R4 together with R5 forms a 5- or 6-membered ring with an interlocking NC tube with an aliphatic or aromatic 6-membered ring. may be decensated and R5 is a hydrophobic, basic or neutral lead chain, X is e a L-amino acid tube containing a hydrophobic chain, or a serine, threonine, a cycloamino acid tube optionally containing an additional heteroatom, or X is -NR2-CH2-C (O) - or a (a) or (b) wherein n is 2, 3 or 4 and W is CH or N, Y is H, -CHF2, -CF3, -CO-NH-alkylene-C6H5, -COOR6, wherein R6 is H or alkyl or - CONR7R8, wherein R7 and R8 are independently H or alkyl, or R7 and R8 together are single alkylene, or Y may be another optionally substituted heterocyclic, and r is 0, 1, 2 or 3. ŕ |