| abstract |
SUMMARY OF THE INVENTION The present invention relates to compounds of general formula (I) having an aspartyl protease inhibitory activity, wherein Z is optionally carbonated (a) or (b) or (c); X and X 'are carbonyl, oxalyl, sulfinyl or sulfonyl; Y and Y '- [C (R 2) 2] p -, -NR 2 -, - [C (R 2) 2] p -M-,> C = C (R 2) 2, or -N (R 2) -CH 2 -; R1 is hydrogen, R6, alkyl, alkenyl, alkynyl, optionally R6-cycloalkyl or cycloalkenyl; and R1 substituents linked to gibberish atoms may form a carbocyclic or heterocyclic ring system; of which R 1 is substituted in any tax; R 4 is -OR 9, -X-R 9, -N (R 9) 2, -C (O) N (R 9) 2, R 6, alkyl, alkenyl, optionally R 6 -cycloalkyl or cycloalkenyl, wherein any R 4 substituent is optionally substituted. one or more vertebrae substituted; R5 is hydrogen, hydroxy, yoke or R1; R6 is optionally substituted aryl, carbocyclic or heterocyclic; R7 is hydrogen, hydroxy or oxyhydrate; Q Methic powders or Nitrogen; M is amino, -NR 2, -oxygen, thio, parentphenyl, parent phenyl; n and p are 1 or 2; q is 1, 2 or 3; and G is imino, -NR 2, -oxygen, thio, parentphenyl, parenthenyl, carbonyl or -C (R 2) 2 -. ŕ |