http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-9900804-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-835 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D257-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-712 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-83 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-62 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-83 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-835 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-712 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 |
| filingDate | 1999-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36700e103de1dcae3c964eb702a5c088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_125673220fc5406c78406ae7c0b8fd2c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c464d16670bc4449758f4c443b7f954 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bdf8e2c4918bfdff801104287c8298df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_920177f67a2df2e5561d8b076d8cd860 |
| publicationDate | 1999-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-9900804-A2 |
| titleOfInvention | Use of Phenoxyacetic Acid and Phenoxymethyl Tetrazole Derivatives with Tumor Effect to Produce Pharmaceutical Compounds and New Compounds |
| abstract | The present invention relates to compounds of the general formula (I) in which the -O-C (R 1) (R 2) - (CH 2) p -A can be attached to the trace, meta or para position; A is carboxyl, C 1 -C 4 alkoxycarbonyl or cyanide or R (G) wherein R 'is hydrogen or C 1 -C 4 alkyl; or A- (CH 2) p -C (R 1) (R 2) - menthol is phenyl, benzyl or indolylmethyl, which may be substituted by R 4; p is 0.1 or 2; R 1 and R 2 independently of one another are hydrogen or C 1-8 -alkyl, or R 1 and R 2 together with the carbon to which they are attached form a C 3-7 -cyclic alkylpyrrolid; R 4 is O-2 chloro, bromo, iodo, fluoro, linear or branched C 1-8 alkyl, hydroxy, C 1-4 alkoxy and / or 1-4 carbon acyl; or the Horn (H) in the general Formula (I) represents naphthyl, which may be substituted by R 4; n is 1-4; m is 0 or 1; B is a straight or branched C 1-10 alkyl piperidine, -CO-C (R 3) -CH-R, -CH = C (R 3) -CO-Ar, -CO-CH (R 3) -CH 2 -R or -CO -CH (R3) -CH2-NR5R6; or -CO-CH (R 3) -CO-Ar when m is 1; R is a hydrogen hydrogen atom, -Ar or -CO-Ar; R3 is hydrogen or C 1-8 alkylpiperidine; R5 and R6 are each independently C1-C4 alkylpiperidine, or R5 and R6 together with the nitrogen atom to which it is attached are piperidine, piperazine, (C1-C8 alkyl) piperazine, monomeric or thiopyrene; Ar is phenyl substituent which may be unsubstituted or may be substituted with one to three chlorine, bromine, iodine, fluorine, straight or branched C 1 -C 8 alkyl, hydroxy, C 1 -C 4 alkoxy and / or C 1 -C 4 acyl substituents. Use of their stereoisomerizing acids or salts thereof with pharmaceutically acceptable acids or bases for the preparation of a medicament having MDM2 antagonist activity. The invention further relates to the novel compounds of general formula (I) and to pharmaceutical compositions containing them. (I) (G) (H) ŕ |
| priorityDate | 1998-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 159.