| abstract |
In the general formula for the title compounds (I) and their intermediates (II), R1 is alkyl, haloalkyl, cycloalkyl, alkynyl, hydroxyalkynyl, alkoxyalkynyl, aryl, arylalkyl, heteroaryl, or heteroarylalkylpiperidate; R2 is hydrogen or alkyl; R3 is aryl, heteroaryl, 2,3-dihydro-benzofuranyl or cycloalkylpiperidate; X is an oxygen or sulfur atom, and Y is a direct bond or -CH 2, - (CH 2) 2 - or -CH 2 O-. The compounds may be used as a novel antagonist of the muscarinic receptor for the treatment of irritable bowel syndrome, urinary retention, or body degenerative disorders ŕ |