| abstract |
The present invention relates to 8-substituted-9H-1,3-dioxolo [4,5-h] [2,3] benzodiazepines of formula (I) wherein X is a carbonyl or methylene group and R1 is hydrogen, hydroxy, \ t 1-4 carbon atoms alkoxy, 1-4 carbon atoms, alkanoyloxy, 1-4 carbon atoms, sulfonyl oxy groups or -NR4R5, or X and R1 together form cyano, tetrazolyl, -CHNOH or -COR6, R2 is nitro , amino, hydroxyamino (-NHOH) or 1-4 carbon atoms, alkanoylamino, R3 is hydrogen, 1-4 carbon atoms or -COR7, Y is hydrogen or methyl, or Y and R3 are 8-carbon and 7 and a pharmaceutically acceptable acid addition salt or quaternary ammonium salt thereof for use in the treatment of (abnormal) lipid-peroxidation-related diseases and conditions, or in the treatment of therapeutic conditions. for the production of structures. HE |