| abstract |
The present invention relates to novel 7-bromo and 7,7-dibromo ceph; m and 7-bromo and 7,7-dibromo cephem derivatives of general formulas (I), (II) and (III), These compounds are derived from esters or amides of 6,6-dibromo-penicillanic acid parent compounds in organic materials, by adding or deactivating certain compounds with or without the addition of tetrabutylammonium bromide. The novel compounds of the present invention are potent inhibitors of proteases, in particular histamine leukocyte elastase (HLE). ŕ |