| abstract |
SUMMARY OF THE INVENTION The present invention relates to nitric cyclic nitric compounds and pharmaceutically acceptable salts thereof, and to pharmaceutical compositions containing them, which are useful in the prevention of free radical induced tissue degeneration, and in the treatment of such diseases in which radicals are formed and oxidized. The novel compounds of the present invention correspond to general formula (I) wherein R 1 and R 2 independently represent C 1-3 alkylpiperidine or R 1 and R 2 taken together form a C 5-6 alkylene ring or (a), Z represents (CHx) n R3 is independently selected from the group consisting of X and n independently of one another, 1 or 2, R3 is hydrogen, C1-4 alkyl, hydroxy, OAc or = O, and ring X is inter alia (b), (d), (e) or a substituent of formula (h), R 4, R 5, R 6 and R 7 independently of one another are hydrogen, C 1-3 alkyl, hydrocarbon or C 1-3 alkoxy, with the proviso that R 1 and R 2 taken together are 5-6; , other than my R3 Reporting Hydrogen Generator. ŕ |