| abstract |
The present invention relates to compounds of general formula (I) in which P is 0 or 1, A is hydrogen or R1- (CH2) q- (X) r- (CH2) s-CO-, of which R1 is hydrogen. imidazolyl, guanidinium, piperazine, marshmallow, piperidine or N (R2), X represents when r is 1, -NH-, -CH2-, -CH = CH-, -C (R16) R17) - an anthracene of the general formula or a cyclohexyl, phenyl, naphthyl or thienyl anthracene, B being an anthracene of the general formula (G) t- (H), of which G and H are an amino acid residual anthrax and optionally having an intermediate amide bond between G and H Y-NR18- may be substituted for daisies; C is a D-amino acid piperidine of the general formula -NH-CH [(CH 2) w -R 4] -CO-, of which R 4 is, inter alia, optionally substituted phenyl, naphthyl, thienyl, pyridyl or indole. D is a D-amino acid piperidine of general formula -NR20-CH [(CH2) k-R5] -CO-, or D is a piperidine of general formula -NR20-CH [(CH2) 1-R5] -CH2-R6 or -NR20 -CH [(CH 2) m -R 5] -CO-R 6 is a piperidine of which R 20 is alkyl, aralkyl, R 5 is the same as R 4, R 6 is piperazinyl, piperidinyl, piperidino, hydroxy piperazin or -N (R 7). E is p is 1, -NH-CH (R 10) - (CH 2) v-R 9 is E, wherein R 9 is, inter alia, hydrogen, imidazolyl, guanidino, piperazin, mofloxyl, piperidine, represents a hydrogen atom, a carboxyl tube, a -CH2-R13 or -CO-R13 tube or a -CH2-OH tube. The compounds of the present invention are useful for stimulating the release of hypophysis in growth hormone and can be used in pharmaceutical or animal production. ŕ |