| abstract |
The compounds of the present invention correspond to the general formula (I) wherein A represents optionally substituted phenyl, naphthyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidyl, thienyl, thiazolyl, oxazolyl or thiadiazolyl lithium, optionally substituted phenyl, pyridyl, thiazolyl, oxazolyl, thienyl, thiadiazolyl, imidazolyl, pyrazinyl, pyridazinyl or pyrimidinyl piperazinyl, R 1 carboxyl, carboxylalkyl, tetrazolyl, tetrazolyl, tetrazolyl, -, hydroxamic acid or succinic acid moiety, or a moiety of the general formula (IA), (IB), (IC) or -CONRaRa1, -CONHSO2Rb or -SO2N (Rc) Rc1, alkyl hydrogen, optionally alkyl, substituted or unsubstituted denotes phenylalkyl or pyridylalkyl piper, R3 denotes hydrogen or methyl or ethyl piper, and D denotes an alkenyl, cycloalkenyl or cycloalkenylalkyl containing a hydrogen atom or a double bond means red. The compounds of the general formula (I) have an analgesic effect on the pain-inducing effect of E-type prestaglandins. ŕ |