| abstract |
The present invention relates to novel rapamycin derivatives of general formula (I), to their preparation, to pharmaceutical compositions containing the new compounds as active ingredients, and to the use of the compounds. In the general formula (I), the major meanings of the substituents are as follows: R 1 is an alkyl, alkenyl, alkynyl, benzyl or chlorobenzyl tube, R 2 is a radical of formula II or III. In particular, the compounds of the present invention exhibit anti-inflammatory and undesirable cellular inhibitory effects. ŕ |