| abstract |
The present invention provides compounds of formula (I) wherein Ar1 is phenyl or cycloalkyl heteroaryl, R is hydrogen, arylalkyl, heteroarylalkyl or hydroxyalkyl, R1 is R3 or R3 is hydrogen, (O) p-port, R2 is hydrogen, alkyl, arylalkyl, or heteroarylalkyl, X1 and X1 'are hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, or hydroxyalkyl, or X1 and X1 may be taken together, X2 and X2 'are hydrogen, or X2 and X2' may be together, X3 is hydrogen, alkyl, aryl, aryl, alkyl, alkyl heteroarylalkyl, or X3 together with one of X1 and X1 'may form a 4-7 membered ring, X4 is hydrogen, alkyl, arylalkyl, or hydroxyalkyl, X5 and X5' are H, or X4 and X5 together = NR5 tube X6 and X6 'are hydrogen, R7R8N, R7R8NCO, R7R8NSO2, R9CO, halogen, cyano or nitro, m is 0, 1, 2 or 3, n is 1, 2 or 3 - these are 1, 2 or 3. and their methods of application. The compounds of the present invention are inhibitors of factor Xa which can be used to treat conditions that can be alleviated by the administration of factor Xa inhibitors. ŕ |