| abstract |
The present invention relates to compounds of general formula (I) (wherein R 1 is hydrogen, alkyl, phenyl or benzyl pt; R 2 is alkyl, alkoxy pt, -O (CH 2) n N (R 13) (R 14) -, - (CH 2) n N (R 13)). (R14) - or -N (R15) (CH2) nN (R13) (R14) -; R3-R12 are hydrogen, halogen, trifluoromethyl, alkyl, cycloalkyl, alkoxy, hydroxy, nitro, cyano, -N (R 13) 2 -, phenyl, phenyloxy, benzyl, or benzyloxy, or R 6 and R 7 together form a benzo ring; R 13 - R 15 are hydrogen, alkyl or cycloalkyl, and n is 1-5; ) and pharmaceutically acceptable salt salts. The present invention relates to a process for the preparation of the compounds, a pharmaceutical composition for use in the treatment of neuro-biological disorders, and a pharmaceutical composition containing them. The compounds of the present invention are antagonists and / or agonists of the metabotropin glutamate receptor. ŕ |