| abstract |
The present invention relates to a process for the preparation of a medicament for the treatment of physiological disorders associated with excess or excessive levels of bradykinin. The composition comprises a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or grapevine thereof, wherein R 1 and R 3 are independently hydrogen, methyl, -C (O) - (C 1-6 alkyl) or -C (O) -Ar, of which Ar is optionally substituted phenyl, R2 is pyrrolidine, hexamethyleneimine, or piperidine. The above physiological disorder may be, for example, rheumatoid arthritis or asthma. ŕ |