| abstract |
The present invention relates to compounds of general formula (I) wherein R1 is optionally substituted phenyl, or optionally substituted heteroaryl, R2 is hydrogen, alkyl, phenyl, aryl or phenyl; R3 is hydrogen, optionally substituted alkyl pendant or alkenyl pendant, or R2 and R3 together with the linked radicals are pendent of formula (II), A is a fused bond, -O-, -CH = CH- or -CC-, (CH2) mO- (CH2) p- or -CH = CH-, X is -CH = CH-, oxygen or sulfur. The present invention relates to the preparation of compounds of the above and to pharmaceutical compositions containing them. The compounds of the present invention have matrix metalloproteinase inhibitory activity. ŕ |