http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-9700954-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c24684033fba97d1ad845ce453a57e3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C315-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N47-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C319-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C279-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C279-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 |
| filingDate | 1997-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44305574566370aa4306ab514c2494b5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90c64912d7c6623d7da928e79502d072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77c4f8ece7377ecb33d61221e930c4ca http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f9eda26b7e9b1dbccc336d2bda756e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2ea97d1d9b8964cd6fee5c803194eb1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c048a1aeb7e80d72c715b6d3235dd99c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b623ad9264aa79f8f5873cdff0b7ed40 |
| publicationDate | 1998-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-9700954-A2 |
| titleOfInvention | Substituted 1-naphthoylguanidine derivatives, their preparation and pharmaceutical compositions containing these compounds |
| abstract | The present invention relates to 1-anthophenylguanidine derivatives of the general formula (I) in which R2, R3, R4, R5, R6, R7 and R8 are, independently of one another, hydrogen, halogen, cyano, nitro, trifluoromethyl or perfluoro. X3YbZ, of which X is oxygen or sulfur or NR (10), CR (11) R (12), C = O or C (= O) O, SO, SO, SO2NR (10), OC = O, NR (10) C = O or NR (10) SO2, R (10), R (11) and R (12) independently of one another are hydrogen, C1-6 alkyl, C1-4 perfluoroalkyl or C3-7 cycloalkyl. , a is 0 or 1, Y is a 1-8 membered alkylene bridge in which a CH2 tube can be replaced by an oxygen or sulfur atom, an NR (13) tube, or an o, p- or m-phenylene tube; R (13) is hydrogen, C 1-6 alkyl, C 1-4 perfluoroalkyl, or C 3-6 cycloalkyl, b is 0 or 1, Z is hydrogen, C 1-7 alkyl, C 3-7 alkyl; O) R (15), SO2R (15), NR (16) R (17) or phenyl, R (15) is N = C (NH2) 2, NR (18) R (19), N (CH2) cNR (18) R (19) or OR (20), of which c is 2 or 3, R (18) and R (19) independently of one another are hydrogen atoms having 1 to 8 carbon atoms or 1 to 4 carbon atoms, or R (19). 18) and R (19) together are a 4- or 5-membered alkylene bridge, which may be replaced by a CH2 tube with an oxygen or sulfur atom, NH, N-CH3, N-benzyl or N- (p-chlorophenyl) tube. , R (20) is hydrogen, C 1-6 alkyl, C 1-4 perfluoroalkyl or C 3-7 cyclic alkyl; R (16) and R (17) independently of one another are hydrogen, C1-C8 alkyl or C 1-4 perfluoroalkyl, or R (16) and R (17) together are a 4- or 5-membered alkylene bridge to a CH2-alkyl. - or replaced by sulfur, NH, N-CH3, N-benzyl or N- (p-chlorophenyl) pipeline; or Z is an N-containing heterocyclic ring having 1 to 9 carbon atoms which is linked via an N or C atom and optionally substituted, with the proviso that in the case of R (4) = alkoxy, R (2), R (3), At least one of the substituents R (5), R (6), R (7) and R (8) has a meaning other than hydrogen and is a physiologically acceptable salt of the above compounds. The compounds of the present invention have anti-ischemic effects, inhibit the antipyretic field of sodium ischemic and reduce the level of ascerol lipid, and can also be used for organ preservation. ŕ |
| priorityDate | 1996-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 188.