http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-229278-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_044b6227c01845d21cc04506d036286e |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-00 |
| filingDate | 2006-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dab050010135fee8b6999d2d8ee86f11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc23d7d2c97a1c3eddce897255bcfd77 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48f3eedb9cbe5709dc0662fb8a35d89b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_967649b52aba6fa650379c9df253f82b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a5b1431f2cd41749d48bcb57050fe3e |
| publicationDate | 2013-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-229278-B1 |
| titleOfInvention | Process for the manufacturing of pharmaceutically active substances with ace - inhibitor effect and intermediates thereof and the novel intermediates |
| abstract | Carbonate containing amino acid (I) is new. Carbonate containing amino acid of formula R3-O-C(O)-O-C(O)-CH(CH3)-N -(-C(O)-O-R3)-CH(COOR2)-(CH2)2-R1 (I) is new. R1aryl or alkyl; R2alkyl; R3alkyl or aralkyl. Independent claims are included for the following: (1) process (M1) for the preparation of compound (I); (2) process (M2) for the preparation of oxazolidinedione derivative of formula (II) involving reacting the compound (I) with thionyl chloride in an organic solvent; (3) process (M3) for the preparation of of formula COOR6-CH(R4)-N(R5)-C(O)-CH(CH3)-NH-CH(COOR2)-(CH2)2-R1 (III) and their salts involving reacting a compound (II), with a divalent amine containing group of formula -N(R5)-CH(R4)-COOR6 (VIII) or its salt; converting the ester of formula (III) thus obtained (where R6 is alkyl or aralkyl), into the corresponding carboxylic acid of formula (III), where R6 is hydrogen; and optionally transforming a compound (III) obtained into its salt. R4optionally substituted alkyl; R5hydrogen or alkyl or the radical of the Formula R5-N-CH-R4 (VII) (where the carbon and nitrogen atoms attached to compounds selected from pyrrolidine-1,2-di-yl, octahydro-indole-1,2-di-yl, octahydro-cyclopenta[b]pyrrole-1,2-di-yl, piperidine-1,2-di-yl, 1,2,3,4-tetrahydro-isoquinoline-2,3-di-yl, decahydro-isoquinoline-2, 3-yl, octahydro-cyclopenta[c]pyrrole-2,3-di-yl, octahydro-isoindole-1,2-yl, 2-aza-spiro[4.4]nonane-2,3-yl, 2-aza-spiro[4.5]decane-2,3-di-yl; R6H, alkyl or aralkyl (preferably hydrogen). [Image] - ACTIVITY : Hypotensive. No biological data is given. - MECHANISM OF ACTION : Angiotensin-converting enzyme (ACE)-inhibitors. |
| priorityDate | 2006-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.