http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-226690-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7042957c266a740dc593e92ea88eb60e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-48 |
| filingDate | 1996-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_711bc13a8d048f15526059d5f32195d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ab9b80d03585c436cdf52b2629de0ac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e8042c403a570bfe54bfe60e2d5ed90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5211c48f62564aa4d4d7229cf6bf042b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6725cabf6d669bd2c23b0ff2bb3db2d9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a88c5f2a76f70f020ef77bd4176c43b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d725ad7eb53cf50f62b52accc67ea21a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8cd788470cfbf9ad8544a37cd0439667 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_546b5692eb445d843d80b52cc3eab615 |
| publicationDate | 2009-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-226690-B1 |
| titleOfInvention | Process for producing fluoxetin |
| abstract | The invention relates to a process for the preparation of N-methyl-[3-phenyl-3-[4-(trifluoromethyl)-phenoxy]-propyl]-amine of the Formula (I) and pharmaceutically acceptable acid addition salts thereof by reaction of N,N-dimethyl-{3-phenyl-3-[4-(trifluoromethyl)-phenoxy]-propyl}-amine of the Formula (III) and ethyl chloro formate and hydrolysis and decarboxylation of the N-methyl-N-ethoxycarbonyl-{3-phenyl-3-[4-(trifluoromethyl)-phenoxy]-propyl}-amine of the Formula (II) and if desired salt formation which comprises carrying out the reaction of the compound of the Formula (III) and ethyl chloro formate in toluene or xylene or a mixture thereof at a temperature below 90 DEG C; removing the contaminations and by-products from the reaction mixture by treatment with a diluted acid; separating the organic phase which contains the urethane derivative of the Formula (II) and reacting said organic phase, without isolating the urethane derivative of the Formula (II), with an alkali hydroxide at the boiling point of the reaction mixture in the presence of water and optionally <u>n</u>-butanol; removing the inorganic compounds; and if desired converting the base of the Formula (I) thus obtained into a pharmaceutically acceptable acid addition salt thereof. The compounds of the Formula (I) are a known valuable antidepressant. |
| priorityDate | 1996-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 97.