| abstract |
The present invention relates to compounds of formula I wherein R 1 is hydrogen, R 2 is hydrogen, R 3 is carboxyl, sulfo, -CONHSO 2 R 8, or optionally substituted tetrazolyl, isoxazolyl or thiadiazolyl, W is sulfur, -SO- or -SO2- or - (CH2) n-, Y is -O- or -S- or -CHR7-, Z is -CH-, -CHR7- or -NR6-, or W and Y, or Y and Z together- CH = CH-, R5 is hydrogen, R6 is oxo (C1-C4) alkyl, R7 is hydrogen, (C1-C4) alkyl or phenyl, R8 is (C1-C4) alkyl, and n is 0, 1 or 2 , subject to certain limitations, and pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing them. llítására. The novel compounds are stimulating amino acid receptor antagonists. ŕ |