| abstract |
The present invention provides pharmaceutical combinations, kits, and compositions for the prevention and / or treatment of benign prostatic hyperplasia of warm-blooded animals, including humans. Combinations or kits include: a) 5? -Reductase inhibitor and antiandrogen, b) EM-652 or prodrug, preferably EM-800 or EM-652 × HCl (antiestrogen) and 5? -Reductase inhibitor, preferably Proscar or Dutasteride, c) EM-1404 or prodrug (17? -hydroxy steroid dehydrogenase inhibitor) and 5? -reductase inhibitor, preferably Proscar or Dutasteride; or d) combinations b) or c) as combinations of an antiandrogen, preferably Flutamide and, if desired, contain a carrier and / or other excipient suitable for a pharmaceutical agent. These combinations inhibit the activity of sexual steroids by inhibiting their formation and / or inhibiting the receptors that they may possess. ŕ |