| abstract |
The compounds of the present invention and their pharmaceutically acceptable salts of formula (I) are P1 and P2 phenyl or heterocyclic; A bond is an optionally substituted chain or A is optionally substituted phenyl or heterocyclic; R1 and R2 are hydrogen, optionally alkyl, alkenyl, alkynyl, alkylthio, cyano, nitro, halogen, trifluoromethyl, pentafluoroethyl, NR12R13, CONR12R13, NR12COR13, S (O) pNR12R13, formyl, trifluoromethoxy, trifluoromethylthio, COR14, CH2R14, CH2OR14, CO2R14 or OR14, wherein p1 or 2, R12, R13 and R14 are hydrogen, alkyl, optionally substituted aryl; or aryl (C 1 -C 6) alkyl; n and m are 0, 1 or 2; R3 is hydrogen or alkyl; R4 is a group of formula (i), X and Y are nitrogen, or one is nitrogen and the other is CR5 or one is CR5 and the other is carbon or CR5; R5, R6, R7 and R8 are hydrogen; substituted alkyl, alkenyl, cycloalkyl, cycloalkylalkoxy, alkynyl, cycloalkoxy, cycloalkylalkyl, alkylthio, cycloalkylthio, cycloalkylalkylthio, alkoxy, hydroxy; , halogen, nitro, trifluoromethoxy, trifluoromethylthio, trifluoromethylsulfonyl, fluorosulfonyl, formyl, alkanoyl, cyano, phenyl or thienyl, NR12R13, CONR12R13 or CO2R14, R12, R13 and R14 are as defined for R1; or R6 and R7 are part of an optionally substituted ring group; and R9 and R10 are hydrogen or alkyl. The present invention encompasses processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and the use of the compounds and pharmaceutical compositions for the treatment of central nervous system disorders such as anxietas. ŕ |