http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-215432-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-04 |
| filingDate | 1990-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1999-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-215432-B |
| titleOfInvention | Process for the preparation of tetrazole acetic acid derivatives having aldose reductase inhibitory activity and pharmaceutical compositions containing them. |
| abstract | The present invention relates to novel tetrazole acetic acid derivatives of the general formula (I) and their salts, wherein R1 is hydrogen, C1-7 alkyl pentane, R2 is hydrogen hydrocarbon, fish petroleum, optionally substituted phenyl pentane, C 1-8 -alkylphthalate, hydroxycarboxylate, C 1-7 -alkylalkoxyphthalate, phenyl-phthalate, C 1-7 -alkylthio-piperidine, phenyl-thio-piperidine, optionally C 1-7 -alkyl-carboxyl-alkyl- - or phenylsulfonylphenyl substituted aminocarbonate, of which the C 1-7 alkylcarbonylphenyl is optionally substituted with phenylcarboxylate; optionally 1-7 Carbonylalkylamino-sulfonylphenyl carbonated with C2-7 alkoxyalkoxy or hydroxy biphenyl; C 1-7 alkylsulfonylphenyl or alkylsulfonylphenyl; piperidino-sulfonylphenylpiperidine and X is -O- or -S-, with the exception of: 5- (2-thienyl) -tetrazol-1-yl / -acetic acid, 5- (2-furyl) -tetrazole -1-yl-acetic acid, 5- (5-bromo-2-furyl) -tetrazol-1-yl-acetic acid, 5- (5-phenylthio-2-furyl) -tetrazol-1-yl acetic acid and its ethyl esters, 5- (5-phenyl-2-furyl) -tetrazol-1-yl-acetic acid and 1-3 carbonylalkyl esters or salts thereof. These compounds of general formula (I) exhibit excellent aldose anti-reductase inhibitory activity, are of low toxicity to the body, and are very active as active ingredients in the prophylaxis and / or therapy of diabetic stone complications. The present invention relates to a process for the preparation of pharmaceutical compositions and active ingredients. ŕ |
| priorityDate | 1989-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 194.