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filingDate 1992-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f1a2bd279b529b16e0f4eb77020dbb0
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publicationDate 1997-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber HU-213101-B
titleOfInvention Process for producing pharmaceutical composition of synergetic gastrocitoprotective activity, containing ranitidine and derivative of the salicylic acid
abstract The present invention relates to a gastrocytoprotective pharmaceutical composition containing as active agents a compound of general formula (I), wherein R means hydrogen or a C1-4alkyl group; R<1> stands for: hydroxyl group; C1-4alkoxy group; or a group of general formula (A), wherein R<2> means hydrogen or benzyl group; and R<3> means a C1-4alkyl group; or stands for a group of general formula (B), wherein R<4> means a C1-4alkyl group, and ranitidine in a weight ratio of 10:1 to 1:10 together with carriers and auxiliaries known per se, and to a process for the preparation thereof. A favourable active agent of general formula (I) is e.g. methyl 4-(3-carboxy-4-hydroxyphenyl)-4-oxo-(2E)-butenoate. The combination of the above active agents according to the invention exerts also an antibacterial effect (against the Helicobacter pylori strain).
priorityDate 1992-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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