http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-208418-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cac023d2e2874224ecbbcccbdea1fc91 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-62 |
| filingDate | 1989-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_216ace23704d32625cf7d98002489840 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29acf45b9554ac8e436d09ccc2d39cd1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c508d1f7a6092a4b07ad1e76979e877e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37a477dc5254b91ed3ccd6aec5ee0fb2 |
| publicationDate | 1993-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-208418-B |
| titleOfInvention | Process for producing phenoxy derivative intermediates |
| abstract | The present invention relates to a process for the preparation of the acetyl mercaptopropylphenoxy derivatives of formula (IIa) wherein R2 is methyl or ethyl, n is 3-8. The process of the present invention is carried out by reacting a compound of formula (VI) wherein R3 is a protecting group with a compound of formula (VII) wherein Y2 is halogen, R2 and n are as defined above, and the protecting group is reacted. are removed or a compound of formula (VI) wherein R3 is as defined above is reacted with a compound of formula (VIIIa) wherein n is as defined above, Y and Y1 are halogen, followed by the compound of formula (IX): R3, Y1 and n are reacted with the above-mentioned alkali metal cyanide, such as sodium cyanide or potassium cyanide, and the resulting compound of formula X, wherein R3 and n are hydrolyzed above, is then converted to an ester with an alcohol and the protecting group removed. The compounds of formula (IIa) may be used as starting materials for the preparation of compounds having a therapeutic effect. ch2ch2ch3 OH ch2ch2ch3 (VI) HS - O / C0CH3 'O- (CH2) nC00R2 ch2ch2ch3 (IX) Y- (CH2) n-V1 (Villa) Y2- (cH2) ncooR2 (VII) (Ha) HU 208 418 BA description range: 6 pages (including 2 tabs) |
| priorityDate | 1988-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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