| abstract |
Piperidine compounds of general formula (XX) are provided which are useful as medicaments for the treatment or prophylaxis of arrhythmia. <CHEM> in which R<1> is a lower alkyl and W is: <CHEM> wherein X is -S-, -SO- or -SO2-; R<2> is hydrogen or -(CH2)n-Y; n is an integer of 1 to 5; Y is an aryl, pyridyl or a substituted pyridyl group; X min is -CO- or -CH(OH)-; p is an integer of 1 to 4; R<1><2> is hydrogen or a lower alkyl group; Y min is -(CH2)m-A; m is 1 or 2; A is an aryl, a substituted aryl, pyridyl or a substituted pyridyl group; R<1><2> and Y may form a 5- or 6-membered ring or a 5- or 6-membered ring having one or more substituents; and R<2><2> is hydrogen, a halogen, a lower alkyl, a lower alkoxy or hydroxy. |