| abstract |
Compounds of the formulan wherein R¹ represents alkoxycarbonyl, aralkoxycarbonyl, alkanoyl, cycloalkylcarbonyl, aralkanoyl, aroyl, heterocyclylcarbonyl, alkylsulphonyl, arylsulphonyl, monoaralkylcarbamoyl, cinnamoyl or α-aralkoxycarbonylaminoalkanoyl and R² represents hydrogen or R¹ and R² together with the nitrogen atom to which they are attached represent a cyclic imide group of the formulan in which P and Q together represent an aromatic system; R³ represents alkyl, cycloalkyl, aryl, aralkyl, heterocyclylalkyl, cyanoalkyl, alkylsulphinylalkyl, carbamoylalkyl or alkoxycarbonylalkyl or, when n stands for zero, R³ can also represent alkylthioalkyl or, when n stands for 1, R³ can also represent alkylsulphonylalkyl; R⁴ represents alkyl, cycloalkyl, cycloalkylalkyl, aryl or aralkyl; R⁵ represents hydrogen and R⁶ represents hydroxy or R⁵ and R⁶ together represent oxo; R⁷ and R⁸ together represent a trimethylene or tetramethylene group which is optionally substituted by hydroxy, alkoxycarbonylamino or acylamino or in which one -CH₂- group is replaced by -NH-, -N(alkoxycarbonyl)-, -N(acyl)- or -S- or which carries a fused cycloalkane, aromatic or heteroaromatic ring; and R⁹ represents alkoxycarbonyl, monoalkylcarbamoyl, monoaralkylcarbamoyl, monoarylcarbamoyl or a group of the formulan in which R¹⁰ and R¹¹ each represent alkyl; nand their pharmaceutically acceptable acid addition salts inhibit proteases of viral origin and can be used as medicaments for the treatment or prophylaxis of viral infections. They can be manufactured according to generally known procedures. |