| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-546
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-545
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- |
| filingDate |
1986-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90e3d8101ec7e8db7adad3e9ab73304b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6a30ad8a466585b00446c955a418ffa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_406d1aab498bf13781b68cfb5eda1a84 |
| publicationDate |
1991-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
HU-202536-B |
| titleOfInvention |
Process for producing 7-imidazolidinone derivative of cefem derivative antibiotics |
| abstract |
The invention relates to a method for purifying an antibiotic derivative. With the process according to the invention, the antibiotic 7- & D-2-amino-2- (4-hydroxyphenyl) -acetamido! -3- & (Z) -1-propenyl! -Ceph-3-em-4-carboxylic acid (BMY -28100) essentially free of its (E) -isomer. The process according to the invention comprises the reaction of a mixture of the (Z) and (E) isomers with a ketone of the formula: wherein the ketone has a molecular weight of less than 200, in the presence of a reagent for Formation of the sodium salt under such reaction conditions that the sodium salt of the obtained imidazolidinol derivative of the (E) -isomer remains in solution and the sodium salt of the imidazolidinol derivative of the (Z) -isomer crystallizes. The (Z) isomer thus obtained is then reconverted to the starting antibiotic. The compounds obtainable according to the invention are useful in medicine for the control of infections. |
| priorityDate |
1985-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |