| abstract |
An improved process for the preparation of purin-9-ylalkylenoxymethyl phosphonic acids, novel nucleotide analogs, typified by (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine, also known as (S)-HPMPA. The improved process employs novel intermediates, is shorter and more efficient by virtue of eliminating large scale isomer separations and ion exchange chromatography, and also is applicable to guanine derivatives as well as to adenine derivatives. |