http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-199786-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7de02e4b28736bfb52de8bb358be203e |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 |
| filingDate | 1981-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de584dac5c6653be195f925518bf96ab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d98a566f0208bd8b08a590eb337d3a0b |
| publicationDate | 1990-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-199786-B |
| titleOfInvention | Process for producing peptide derivatives suitable for treating high blood pressure |
| abstract | 31 Methods are claimed for preparing aminoacylthio-alkanoyl amino acid derivs. of formula (I) - R-A-S-(CH2)n-CHR1-CO-R2 (I) - (where R is H, t-butyloxycarbonyl, cyclopentenecarbonyl-L-lysyl, pyro-L-glutamyl-L-lysyl, L-lysyl, L-arginyl, pyro-L-glutamyl or R', where R' is formyl, acetyl, propionyl, butyryl, phenylacetyl, phenylpropionyl, benzoyl or cyclopentanecarbonyl; A is D- or L-Phe, -Ala, -Trp, -Tyr-, -Gly, -Lle, -Leu, -His or -Val; R1 is H or Me; R2 is L-proline, L-2,4-dehydroproline, DL-3, 4-dehydroproline, L-3-hydroxyproline, L-4-hydroxyproline, L-thiazolidine-4-carboxylic acid or L-5-oxoproline; n = 0 or 1, provided that R1= Me when n= 0 and that the CH2CHR1 gp. is in the D configuration when n= 1 and R1 = Me). - Typical methods include (a) reacting R-A with an aryl or alkyl thiol in the presence of a coupling agent, opt. deprotecting the product and reacting it with an R' coupling cpd., reacting the product with MHS (M= H or alkali metal) to form R-A-SH, reacting this with acrylic or methacrylic acid to form R-A-S-CH2-CHR1-COOH (II), opt. resolving this to isolate the isomer with CH2CHR1 in the D configuration, and coupling the product with R2; (b) reacting R-A with pentachlorophenol, pentafluorophenol or N-hydroxysuccinimide, opt. deprotecting the product and reacting it with a R' coupling cpd., reacting the product with HS(CH2)nCHR1COOH, opt. resolving the product and coupling with R2; etc. |
| priorityDate | 1980-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 353.