| abstract |
Pyrimidoquinoline derivs. of formula (I) and their acid addn. salts are new. R=1-3C alkyl or allyl; R2=H, Me, Cl or Br; R1=NH2, NHR3 or NR4R5; R3=Me, Et, nPr or R6CO; R6=1-3C alkyl or phenyl substd. by (R7)n; R7=H, Cl, F, Br, Me, Et, MeO, EtO or CF3; n= 0-2; R4 and R5=Me, Et or n-Pr. - Also claimed is the trans-(-)stereoisomer of (I) of formula (II); and the trans-(+)-stereoisomer of formula (IIa). Intermediate of formula (III), their trans-(-)-stereoisomers (IV) and trans-(+)-stereoisomers (IVa) and their acid addn. salts are new. R8=H, CN or 2-4C alkoxycarbonyl. |