| abstract |
The invention relates to a novel process for the preparation of histamine H2-receptor antagonists of general formula I, wherein A, m, Z, n and R1 have the meanings indicated, and their non-toxic, pharmaceutically acceptable salts, hydrates and solvates. These compounds are obtained by reacting a substituted ethanediamide of the general formula II with a compound of the general formula R-S-Rworin R has the meanings indicated, to form a ring. The compounds of the invention are novel anti-ulcer agents. |