| abstract |
New compounds of formulas I and II n and the pharmaceutically acceptable acid addition salts thereof, whereinn M is selected from hydrogen, morpholino, benzylamino, di-n-lower alkylamino, n-lower alkylamino andn wherein Ar is optionally substituted phenyl; Z, and Z 2 are each independently selected from CH 2 , CHOB and C = 0, wherein B is selected from hydrogen and alkanoyl; Y is oxygen or nothing; n is an integer from 0-4 but cannot be zero when Z, is CHOB; m is an integer from 0-4 but cannot be zero when 2 2 is CHOB; R 1 , R 2 and R 3 are each independently hydrogen, halogen, aydroxy, trifluoromethyl, alkyl or alkoxy; R 4 is lower alkyl; and R 5 is hydrogen or lower alkyl, nare antihistamines and are therefore useful in the treatment of respiratory diseases including asthma, hay fever, allergies and the common cold. They are also vasodilators. |