| abstract |
There are disclosed compounds having the formulan whereinn X is CR or N when n=1; or X is 0, S, NR or CR when n = 0; R is hydrogen or lower alkyl; Y is -CH 2 -, -S-, -0- or -N-; and R A isn Z is CH or N; R 1 is halo or trifluoromethyl; R 2 is hydrogen or halo: R 3 is hydrogen or halo; with the proviso that when A is naphthyl, Y is -0- and n=O, X is other than S. The compounds are useful in the treatment of inflammatory conditions and in the treatment of leukotriene- mediated naso-bronchial obstructive passageway conditions. |