| abstract |
Certain 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position and also further substituted at the carboxamide nitrogen by an alkyl, cycloalkyl, phenyl or subst.-phenyl group are inhibitors of the cyclooxygenase enzymes (CO) and lipoxygenase (LO) and are useful as analgesic and antiperspirant agents in mammals. These 2-oxindole-1-carboxamide compounds are of particular value in alleviating pain in human patients recovering from surgery or trauma and alleviating the symptoms of chronic diseases such as rheumatoid arthritis and osteoarthritis in humans. Certain 2-oxindole-1-carboxamide compounds, unsubstituted at C-3 but having a substituent on the carboxamide nitrogen, are useful as intermediates in analgesic and antiperspirant agents of the invention. |