http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-194272-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6963410cbb03c6b79d727ad6b97989a4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H17-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-00 |
| filingDate | 1984-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20ec0a86275aa84173bc9cb96303423b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd9c646b1081553d9cd5e072767dab10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3facc8ea9bde5c51fc17edd9490254be http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43d451d0ad1d5d70487507711c1d5f56 |
| publicationDate | 1988-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-194272-B |
| titleOfInvention | Process for producing 7,16-dioxa-2-aza-10-0-kladinosyl-12-0-dezozaminyl-4,5-dihydroxy-6-ethyl-3,5,9,11,13,15-hexamethyl-bicyclo-square bracket opened-11,2,1-square bracket closed-hexadeca-1/2/-en-8-one |
| abstract | The invention relates to a new process for the manufacture of 7,16-dioxa-2-aza-10-0-cladinosyl-12-0-desosaminyl-4,5-dihydroxy-6-ethyl-3,5,9,11,13,15-hexamethyl- bicycio[11.2.1]-hexadeca-1(2)-ene-8-one, a semisynthetic macrolide antibiotic of the erythromycin A series, by means of Beckmann rearrangement of erythromycin A oxime monohydrochloride or dihydrochloride with aromatic sulfochlorides of the formula 4-R-C 6 H 4 SO 2 Cl, wherein R stands for C 1 -C 3 alkyl, halogen, acylamino of the formula -NHCOR,, wherein R 1 stands for C 1 -C 3 alkyl, in the presence of bases, without preliminary isolation of erythromycin A oxime. There is also provided a novel imtermediate erythromycin A oxime dihydrochloride and the preparation thereof from erythromycin A with hydroxylamine hydrochloride. |
| priorityDate | 1983-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.