| abstract |
1,3,5-Trisubstituted 1,2,4-triazole derivatives of the formula <IMAGE> in which R1 represents a phenyl radical or a naphthyl radical optionally substituted by one or more fluorine, chlorine and/or bromine atom(s), alkyl radical(s), alkoxy radical(s), nitro group(s), trifluoromethyl radical(s), alkylthio radical(s), alkylsulphinyl radical(s) and/or alkylsulphonyl radical(s), R2 denotes a phenyl radical or a thienyl radical optionally substituted by one or more fluorine, chlorine and/or bromine atom(s), alkyl radical(s), alkoxy radical(s), nitro group(s), trifluoromethyl radical(s), alkylthio radical(s), alkylsulphinyl radical(s) and/or alkylsulphonyl radical(s), R3 represents an alkyl radical optionally substituted by one or more fluorine and/or chlorine atom(s), hydroxyl group(s), alkoxycarbonyl radical(s), cyano group(s) and/or pyridyl radical(s), an alkoxycarbonyl radical, an oxoalkyl radical or a phenylalkyl radical substituted in the phenyl ring by one or more fluorine and/or chlorine atom(s) and n is 0, 1 or 2, in particular having anti-inflammatory and antirheumatic action. |