http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HU-193563-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a4a32efff8389803afe678eaa60c84ad |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-02 |
| filingDate | 1984-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30d4e3c353cb1ae5bfb15fc061eaa03c |
| publicationDate | 1987-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | HU-193563-B |
| titleOfInvention | Process for producing n-/cyclopropyl-methyl/-6,14-endoethano-7-/1-hydroxy-1,2,2-trimethyl-propyl/-dihydronormorphin-6-methylester |
| abstract | N-(cyclopropyl-methyl) -6,14-endo-ethano-7-(1-hydroxy -1, 2, 2-trimethyl-propyl)-dihydro -normorphine-6-methylester is prepd. from the Diels-Alder reaction prod. of thebaine with acrolein by reacting the resulting 6, 14-endo-etheno -7-formyl-tetrahydro -thebaine with methyl-magnesium-iodide, oxidizing the resulting 6, 14-endo-etheno-(1-hydroxy -ethyl) -tetrahydro -thebain with potassium-permanganate, hydrogenating the resulting 6, 14-endo-etheno-7-acetyl -tetrahydro-thebaine on a palladium catalyst, reacting the resulting 6, 14-endo-ethano-7-acetyl -tetrahydro-thebaine with tert. -butyl-magnesium-chloride, reacting the resulting 6, 6,14-endo-ethano-7-(1-hydroxy - 1, 2, 2-trimethyl -propyl) -tetrahydro-thebaine with cyanogen-bromide, reacting the resulting N-cyano-6,14-endo-ethano -7-(1-hydroxy-1, 2, 2-trimethyl-propyl) -tetrahydro-thebaine with potassium-hydroxide at 210 deg. C, andreacting the resulting 6,14-endo-ethano-7-(1-hydroxy -1, 2, 2-trimethyl -propyl)-dihydro -normorphine-6-methylester with bromo-methyl-cyclopropane. |
| priorityDate | 1983-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.